Ultra-modern stay in Rome
Located on Via Cola di Rienzo, Twenty One Hotel is situated in the elegant Prati district, home to the Vatican and Saint Peter's Basilica. You’ll be staying in an elegant and stylish en-suite room which features high levels of attention to detail. The modern rooms are equipped with Wi-Fi, TV, air-conditioning and private bathroom. After a restful sleep, you can enjoy a continental breakfast spread and other traditional and local dishes for lunch and dinner. Throughout the day you’ll be in a prime position to explore the delights of Rome. Vatican City can be reached in 15 minutes on foot, and Piazza del Popolo and Piazza di Spagna are also within walking distance. The nearest train station is just 500 yards from your doorstep.
Facilities
Food & Drink
- Bar
- Breakfast room
- Restaurant
Use of these facilities may attract additional charges. All hotel and room facilities are subject to safety and wellbeing measures (including height and/or weight restrictions on slides and rides), board basis, seasonal availability, opening times, age, and dress code.
Find out more about Vatican Prati
Over on the west side of the Tiber River, the Vatican and Prati neighbourhood is a vibrant and elegant area in Rome, bursting with history, culture, and charm. Home to the Vatican City, this district offers immediate access to world-famous landmarks like St. Peter’s Basilica, the Sistine Chapel, and the Vatican Museums – perfect if you’re fascinated by Rome’s art and history scene.
Prati’s wide, tree-lined streets and stylish boutiques make it a delight to explore. Via Cola di Rienzo is a shopping haven, offering everything from Italian fashion to artisanal goods. Nearby, Castel Sant’Angelo provides superb views and a glimpse into Rome’s imperial past. Often ignored by Rome’s visitors altogether, this area is a haven of under-the-radar treasures – it’s also within easy walking distance of the Vatican, so you can’t go wrong.
Dining here is a feast for the senses. Enjoy Roman classics at local trattorias or opt for modern Italian cuisine at chic restaurants. Get to know the piazzas, the coffee shops, and the gelato shops off the main tourist paths, like Piazza Cavour, Gianfornaio, and Neve di Latte. Close to the historic centre yet quieter, this charming area – that often gets overlooked by tourists – offers a perfect balance of culture and relaxation in the Eternal City.
Prati’s wide, tree-lined streets and stylish boutiques make it a delight to explore. Via Cola di Rienzo is a shopping haven, offering everything from Italian fashion to artisanal goods. Nearby, Castel Sant’Angelo provides superb views and a glimpse into Rome’s imperial past. Often ignored by Rome’s visitors altogether, this area is a haven of under-the-radar treasures – it’s also within easy walking distance of the Vatican, so you can’t go wrong.
Dining here is a feast for the senses. Enjoy Roman classics at local trattorias or opt for modern Italian cuisine at chic restaurants. Get to know the piazzas, the coffee shops, and the gelato shops off the main tourist paths, like Piazza Cavour, Gianfornaio, and Neve di Latte. Close to the historic centre yet quieter, this charming area – that often gets overlooked by tourists – offers a perfect balance of culture and relaxation in the Eternal City.
Average weather in RomeThis shows you historical average daytime temperatures, not a real-time forecast. It’s a great way to check if a destination’s typical weather suits your holiday vibe.
This shows you historical average daytime temperatures, not a real-time forecast. It’s a great way to check if a destination’s typical weather suits your holiday vibe.
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