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The NSE is the largest medical charity in its field in the UK. Doctors and scientists at the charity are making a major contribution to the world's research into the causes, diagnosis and treatment of epilepsy, pioneering novel diagnostic techniques and making improvements in both surgical and medical treatment of the condition. The world's most advanced MRI (magnetic resonance imaging) unit to be dedicated solely to the identification of the causes of epilepsy is located at NSE's South Bucks headquarters. Work at this unit has meant that up to 70 percent of people with epilepsy can now have the cause of their epilepsy identified.

Epilepsy is the most common serious neurological condition affecting one in 150 adults in the UK. Around 1,000 people die from epilepsy related complications a year - a proportionately higher mortality rate than asthma.